Cleveland at Pittsburgh 1:00 PM ET
AFC North matchups between the Pittsburgh Steelers and Cleveland Browns are always heated given the teams' proximity and history, but things could be heightened in the newest version of the rivalry Sunday at Heinz Field.
Cincinnati at Indianapolis 1:00 PM ET
It's been an up and down first season with the Indianapolis Colts for veteran quarterback Philip Rivers, who was signed for $25 million to get a team with high expectations back to the playoffs.
Detroit at Jacksonville 1:00 PM ET
Inconsistency has plagued the Detroit Lions and Jacksonville Jaguars. At least, that's what their coaches have to say about their one-win teams.
Atlanta at Minnesota 1:00 PM ET
Killer instinct has eluded both the Atlanta Falcons and Minnesota Vikings through five weeks of the NFL season, a big reason why the teams enter Sunday's meeting in Minneapolis with a combined 1-9 record.
Washington at N.Y. Giants 1:00 PM ET
The New York Giants will try to earn their first win of the season when they host the Washington Football Team on Sunday afternoon in East Rutherford, N.J.
Chicago at Carolina 1:00 PM ET
The Chicago Bears and Carolina Panthers are among the NFL's early surprises.
Baltimore at Philadelphia 1:00 PM ET
Philadelphia Eagles defensive coordinator Jim Schwartz has a healthy respect for Lamar Jackson, and that has not waned even though the speedy Baltimore Ravens quarterback has been slow out of the blocks to start this season.
Houston at Tennessee 1:00 PM ET
Perhaps the clearest confirmation of the Tennessee Titans' status as a legitimate Super Bowl contender came on Tuesday night in Nashville against the previously unbeaten Buffalo Bills.
Denver at New England 1:00 PM ET
After two postponements due to COVID-19 positive tests in New England, the Patriots and Denver Broncos are ready to play Sunday in Foxborough, Mass.
N.Y. Jets at Miami 4:05 PM ET
The much-improved Miami Dolphins, coming off an impressive 43-17 win over the San Francisco 49ers, must protect against a letdown when the winless New York Jets visit on Sunday.
Green Bay at Tampa Bay 4:25 PM ET
It's not like the Green Bay Packers need the help, but they're about to get it anyway.
L.A. Rams at San Francisco 8:20 PM ET
Two teams seeking to recapture the magic that led to recent Super Bowl appearances go head to head Sunday night when the Los Angeles Rams visit the San Francisco 49ers in an NFC West matchup.